Coriolus Versicolor PSP is a biological response modifier. here is more research on PSP

Pharmacodynamic studies prove that PSP has a very obvious effect of strengthening health and energy to eliminate substances and is a new type of BRM (Biological response Modifier)

  1. PSP can enhance the immune function of a normal body.
    • Promote the expression of IL-6 gene of peripheral blood lymphocytes (PBL) in humans and hence induce the production of interlukin 6 (IL-6), and also activate white blood cells to increase the production of interferon alpha and game by 2 to 4 times.
    • Greatly increase the phagocytic index and raise HC50, IgG and PFC values in mice; accelerate PBL from G1 to S period and promote the proliferation of PBL.
    • Promote the proliferation of T-lymphoctes and pre-T cells in the thymus and spleen.
  1. PSP can antagonize tumour-induced immuno-suppression in animals
    • Arrest the atrophy of thymus in sarcoma bearing mice.
    • Antagonize the swelling of liver dur to Ehrlich ascites carcinoma.
    • Counteract the inhibition effect on antibody caused by sarcoma in mice.
    • Raise the value of serum complement C3 in sarcoma bearing mice.
  1. PSP can antagonize immuno-suppression caused by chemotherapeutic drugs.
    • Obviously antagonize the lowering action of white blood cells caused by cyclophosphamide and shorten the recovery time of WBC.
    • Obviously counteract the inhibitory action of cyclophosphamide on interleukin-2 (IL-2) and NK cells.
    • Restore the delayed type hypersensitivity (DTH) reaction inhibited by cyclophosphamide.
  1. PSP can inhibit the growth of cancer cells in men and animals.
    • PSP (50mg/kg, ip or po) can inhibit the growth of sarcoma 180 in mice. The inhibition rates are 46-68%.
    • A test using radioactive precursors shows that PSP (100microgram/ml) can inhibit the synthesis of nucleic acid of ehrlich ascites carcinoma. The inhibition rates of RNA and DNA are 51% and 45% respectively.
    • PSP can inhibit the growth of P388 leukemia cells, myeloma cells, hepatoma, Lewis lung cancer in mice. It can also inhibit the growth of human liver cancer, colon cancer, nasopharyngeal carcinoma, stomach cancer, human lung adenocarcinoma, monocytic leukemia and human skin histiocytic lymphoma. It can also cause the swelling of cancer cells and chromosome aggregation
    • That antilymphatic serum (ALS) can counteract the inhibitory effect of PSP on sarcoma provides counter-evidence that anti-tumour activity of PSP is related to the increase of T-lymphocytes.
  1. Other effects of PSP.
    • Obviously improve the appetite of mice being administered with cyclophosphamide.
    • Obviously decrease the painful reaction of animal caused by hot plate, acetic acid and electric stimulation.
    • inhibit the central nervous system and decrease the spontaneous activity of mice.
    • In terms of the survival time of mice in oxygen-lacking conditions, PSP test group has a much higher ability of anoxia tolerance.

(Source: http://psp-research.com)

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